MicroRNAs: Critical Regulators of Development, Cellular Physiology and Malignancy

摘要: MicroRNAs (miRNAs) are 18-24 nucleotide RNA molecules that regulate the stability or translational efficiency of target mRNAs. These regulatory RNAs function by acting as sequence-specific guides which recruit a large protein complex known RNA-induced silencing complex, RISC, to mRNAs subsequently silenced. Diverse functions have been attributed miRNAs including regulation cellular differentiation, proliferation, and apoptosis. Moreover, significant evidence has accumulated implicating fundamental role for in development cancer. We recently demonstrated oncogenic transcription factor c-Myc regulates group mir-17 cluster. This represents first documented example mammalian miRNA expression. it was independently cluster accelerates c-Myc-induced lymphomagenesis an vivo mouse model. Together, these studies support important this c-Myc-mediated tumorigenesis. also two pro-proliferative, pro-apoptotic E2F1. Herein, we propose model prevents excessive E2F1 activity, thereby apoptosis, response activation c-Myc.