Topographic and Tomographic Properties of Forme Fruste Keratoconus Corneas

摘要: PURPOSE. To investigate the efficacy of topography and tomography indices combined in discriminant functions to detect mild ectatic corneas. METHODS. The authors retrospectively reviewed data 143 eyes separated into three groups by Corneal Navigator OPD scanning system (Nidek, Gamagori, Japan): normal (N; LASIK surgery with a 2-year follow-up; n 72), forme fruste keratoconus (N contralateral KC; FFKC; 40), KC (n 31). Topography indices, corneal thickness spatial profile (CTSP), anterior posterior curvature profiles were obtained Orbscan IIz (Bausch & Lomb Surgical, Rochester, NY). percentage increase (PTI) from thinnest point periphery, variation (PVAK), calculated compared Kruskal-Wallis test. usefulness these discriminate among was assessed receiver operating characteristic (ROC) curve analysis. RESULTS. Posterior elevation (TP), all positions CTSP, PTI for distances TP, PVAK 5- 7-mm distance TP significantly different FFKC N group. between reached an area under ROC 0.98 0.99, respectively. maximum central most important contributors function. CONCLUSIONS. Indices generated measurements over entire cornea centered on can identify very forms ectasia undetected Placido-based neural network program. (Invest Ophthalmol Vis Sci. 2010;51:5546‐5555) DOI:10.1167/iovs.10-5369