Expression of H type 1 antigen of ABO histo-blood group in normal colon and aberrant expressions of H type 2 and H type 3/4 antigens in colon cancer.
作者： Noboru Fujitani , Yuhua Liu , Shuji Toda , Kazuo Shirouzu , Torahiko Okamura
关键词: Chemistry 、 Fucosyltransferase 、 Cancer 、 Antigen 、 Colorectal cancer 、 Monoclonal antibody 、 Molecular biology 、 ABO blood group system 、 H antigen 、 Rectum
摘要: We have immunohistochemically examined the distribution of H antigens type 1, 2 and 3/4 chains ABO(H) histo-blood group system in human normal colon cancer using three monoclonal antibodies specific for each 1/2, 2, chain. unexpectedly found that mucosa from secretors but not nonsecretors expressed only 1 did express or 3/4. The was goblet cells. Positive cells expressing were decreased number progressively proximal to rectum. In tumors, 4 (57%) 7 tissues no whereas all 8 distal 1. aberrant expressions (47 67%, respectively) both colon. Tumors any antigens. Our results suggested expression regulated by FUT2-encoded Se alpha(1,2)fucosyltransferase. However, UEA-I-positive substance(s) rather than uniquely throughout cancers nonsecretors.
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