The transcription factor FOXL2: at the crossroads of ovarian physiology and pathology

摘要: FOXL2 is a gene encoding forkhead transcription factor. Its mutations or misregulation have been shown to cause the blepharophimosis-ptosis-epicanthus inversus (BPES) syndrome and more recently associated with development of Ovarian Granulosa Cell Tumors (OGCT). BPES genetic disorder involving mild craniofacial abnormalities often premature ovarian failure. OGCTs are endocrine malignancies, accounting for 2-5% cancers, treatment which still challenging. In this review we summarize recent data concerning transcriptional targets molecular partners, its post-translational modifications, involvement in newly discovered pathophysiological processes. ovary, involved regulation cholesterol steroid metabolism, apoptosis, reactive oxygen species detoxification cell proliferation. Interestingly, one main roles also preserve identity granulosa cells even at adult stage prevent their transdifferentiation into Sertoli-like cells. All these advances indicate that central maintenance. The elucidation impact germinal somatic will allow better understanding pathogenesis OGCTs.