EFHD2 promotes epithelial-to-mesenchymal transition and correlates with postsurgical recurrence of stage I lung adenocarcinoma

摘要: Surgery is the only curative treatment for early-stage non-small cell lung cancer (NSCLC) patients. However, approximately one-third of these patients develop recurrence, which remains main cause mortality in postsurgical NSCLC. Many molecular markers have been proposed to predict recurrence disease, but no marker has demonstrated sufficient reliability clinical application. In present study, novel protein EF-hand domain-containing D2 (EFHD2) was identified as expressed highly metastatic tumor cells. EFHD2 increased formation protrusive invadopodia structures and migration invasion abilities promoted epithelial-to-mesenchymal transition (EMT) character adenocarcinoma We that mechanism enhancing EMT occurs partly through inhibition caveolin-1 (CAV1) progression. The expression significantly correlated with stage I Kaplan-Meier-plotter database search our retrospective cohort study (HR, 6.14; 95% CI, 2.40-15.74; P < 0.001). Multivariate Cox regression analysis revealed an independent predictor this disease. conclude associated metastasis could serve adenocarcinoma.