A prospective cohort study characterising the role of anogenital warts in HIV acquisition among men who have sex with men: a study protocol.

作者: Brandon Brown , Mariam Davtyan , Segundo R Leon , Hugo Sanchez , Gino Calvo

DOI: 10.1136/BMJOPEN-2014-005687

关键词: Men who have sex with menChlamydiaCohort studyFamily medicineGynecologyReproductive healthAcquired immunodeficiency syndrome (AIDS)MedicinePublic healthGenital wartsSyphilis

摘要: Introduction The HIV epidemic in Latin America is concentrated among men who have sex with (MSM) and transgender women (TGW) transmission predominately occurring during unprotected anal intercourse. This mode of also responsible for other sexually transmitted infections (STIs) such as herpes simplex, chlamydia gonorrhoea, human papillomavirus (HPV)/genital warts syphilis. Studies assessing the prevalence HPV MSM not addressed role genital HPV-related diseases acquisition infection. Community-based testing programmes are a potentially important way to remove barriers including stigma individuals learn about their STI status. Methods analysis prospective cohort study will recruit 600 MSM/TGW at community centre Lima, Peru, named Epicentro. Half participants history or current anogenital (AGW), half no AGW. We measure STIs syphilis, HPV, gonorrhoea HIV-incidence two groups. To best our knowledge, it be first that specifically examines impact on incident help understand relationship between AGW infection Peru. Furthermore, may facilitate development preventive intervention strategies reduce prevent manifestations good proxy risk. Ethics dissemination was approved by institutional review boards University California, Los Angeles (UCLA) USA Impacta Study findings shared Peruvian Ministry Health well international national public health organisations. results translated into Spanish participants. Trial registration number Clinicaltrials.gov NCT01387412

参考文章(22)
Jin FengYi Jin FengYi, GP Prestage, J Imrie, SC Kippax, B Donovan, DJ Templeton, A Cunningham, A Mindel, PH Cunningham, JM Kaldor, AE Grulich, Anal sexually transmitted infections and risk of HIV infection in homosexual men. Journal of Acquired Immune Deficiency Syndromes. ,vol. 53, pp. 144- 149 ,(2010) , 10.1097/QAI.0B013E3181B48F33
Maria Gabriella Donà, Guido Palamara, Aldo Di Carlo, Alessandra Latini, Amina Vocaturo, Maria Benevolo, Fulvia Pimpinelli, Amalia Giglio, Domenico Moretto, Giampaolo Impara, Massimo Giuliani, Prevalence, genotype diversity and determinants of anal HPV infection in HIV-uninfected men having sex with men. Journal of Clinical Virology. ,vol. 54, pp. 185- 189 ,(2012) , 10.1016/J.JCV.2012.02.014
JOHN-ARNE R??TTINGEN, D. WILLIAM CAMERON, GEOFFREY P. GARNETT, A systematic review of the epidemiologic interactions between classic sexually transmitted diseases and HIV: how much really is known? Sexually Transmitted Diseases. ,vol. 28, pp. 579- 597 ,(2001) , 10.1097/00007435-200110000-00005
CF Caceres, W Mendoza, Monitoring trends in sexual behaviour and HIV/STIs in Peru: are available data sufficient? Sexually Transmitted Infections. ,vol. 80, pp. ii80- ii84 ,(2004) , 10.1136/STI.2004.012021
Helen A Weiss, Judith R Glynn, Pamela L Cross, James A Whitworth, Richard J Hayes, Esther E Freeman, Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS. ,vol. 20, pp. 73- 83 ,(2006) , 10.1097/01.AIDS.0000198081.09337.A7
Brandon Brown, Mariam Davtyan, Jerome Galea, Erica Chow, Segundo Leon, Jeffrey Klausner, The role of human papillomavirus in human immunodeficiency virus acquisition in men who have sex with men: a review of the literature. Viruses. ,vol. 4, pp. 3851- 3858 ,(2012) , 10.3390/V4123851
Marie Laga, Abib Manoka, Mayimona Kivuvu, Bazola Malele, Mulivanda Tuliza, Nzilambi Nzila, Johan Goeman, Frieda Behets, Veronique Batter, Michel Alary, William L Heyward, Robert W. Ryder, Peter Piot, Non-ulcerative sexually transmitted diseases as risk factors for HIV-1 transmission in women: results from a cohort study. AIDS. ,vol. 7, pp. 95- 102 ,(1993) , 10.1097/00002030-199301000-00015
K J Craib, D R Meddings, S A Strathdee, R S Hogg, J S Montaner, M V O'Shaughnessy, M T Schechter, Rectal gonorrhoea as an independent risk factor for HIV infection in a cohort of homosexual men. Sexually Transmitted Infections. ,vol. 71, pp. 150- 154 ,(1995) , 10.1136/STI.71.3.150
Jesse L Clark, Eddy R Segura, Silvia M Montano, Segundo R Leon, Tadeusz Kochel, Hector J Salvatierra, Jorge Alcantara, Carlos F Cáceres, Thomas J Coates, Jeffrey D Klausner, Routine laboratory screening for acute and recent HIV infection in Lima, Peru Sexually Transmitted Infections. ,vol. 86, pp. 545- 547 ,(2010) , 10.1136/STI.2010.042697
Dorothy A Machalek, Mary Poynten, Fengyi Jin, Christopher K Fairley, Annabelle Farnsworth, Suzanne M Garland, Richard J Hillman, Kathy Petoumenos, Jennifer Roberts, Sepehr N Tabrizi, David J Templeton, Andrew E Grulich, Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis Lancet Oncology. ,vol. 13, pp. 487- 500 ,(2012) , 10.1016/S1470-2045(12)70080-3