Choosing Antibiotics for Intra-Abdominal Infections: What Do We Mean by “High Risk”?

作者: Brian R. Swenson , Rosemarie Metzger , Traci L. Hedrick , Shannon T. McElearney , Heather L. Evans

DOI: 10.1089/SUR.2007.041

关键词: TazobactamPseudomonas aeruginosaMicrobiologyImipenemMedicinePiperacillinDrug resistanceAbdominal InfectionCilastatinAntibioticsInternal medicine

摘要: Abstract Background: The definition of “high risk” in intra-abdominal infections remains vague. purpose this study was to investigate patient characteristics associated with a high risk isolation resistant pathogens from an source. Methods: All complicated and abdominal organ/space surgical site treated over ten-year period single hospital were analyzed. Infections categorized by pathogen(s). Organisms designated “resistant” those that had reasonable probability being the broad-spectrum agents imipenem/cilastatin piperacillin/tazobactam, included non-fermenting gram-negative bacilli (e.g., Pseudomonas aeruginosa), gram-positive pathogens, vancomycin-resistant enterococci, fungi. Patient analyzed define associations pathogens. Results: A total 2,049 during study, which 1,...

参考文章(13)
John E. Mazuski, Robert G. Sawyer, Avery B. Nathens, Joseph T. DiPiro, Moshe Schein, Kenneth A. Kudsk, Charles Yowler, The Surgical Infection Society guidelines on antimicrobial therapy for intra-abdominal infections: evidence for the recommendations Surgical Infections. ,vol. 3, pp. 175- 233 ,(2002) , 10.1089/109629602761624180
Michael G. Hughes, Tae W. Chong, Robert L. Smith, Heather L. Evans, Timothy L. Pruett, Robert G. Sawyer, Comparison of fungal and nonfungal infections in a broad-based surgical patient population. Surgical Infections. ,vol. 6, pp. 55- 64 ,(2005) , 10.1089/SUR.2005.6.55
Avery B. Nathens, Ori D. Rotstein, John C. Marshall, Tertiary Peritonitis: Clinical Features of a Complex Nosocomial Infection World Journal of Surgery. ,vol. 22, pp. 158- 163 ,(1998) , 10.1007/S002689900364
Philippe Montravers, Annie Chalfine, Remy Gauzit, Alain Lepape, Jean Pierre Marmuse, Corinne Vouillot, Claude Martin, Clinical and therapeutic features of nonpostoperative nosocomial intra-abdominal infections Annals of Surgery. ,vol. 239, pp. 409- 416 ,(2004) , 10.1097/01.SLA.0000114214.68169.E9
WILLIAM A. KNAUS, ELIZABETH A. DRAPER, DOUGLAS P. WAGNER, JACK E. ZIMMERMAN, APACHE II: a severity of disease classification system. Critical Care Medicine. ,vol. 13, pp. 818- 829 ,(1985) , 10.1097/00003246-198510000-00009
John E. Mazuski, Ellen J. Baron, Robert G. Sawyer, Avery B. Nathens, Joseph T. DiPiro, Timothy Buchman, E. Patchen Dellinger, John Jernigan, Sherwood Gorbach, Anthony W. Chow, John Bartlett, Joseph S. Solomkin, Guidelines for the Selection of Anti-infective Agents for Complicated Intra-abdominal Infections Clinical Infectious Diseases. ,vol. 37, pp. 997- 1005 ,(2003) , 10.1086/378702
John E. Mazuski, Robert G. Sawyer, Avery B. Nathens, Joseph T. DiPiro, Moshe Schein, Kenneth A. Kudsk, Charles Yowler, The Surgical Infection Society guidelines on antimicrobial therapy for intra-abdominal infections: an executive summary. Surgical Infections. ,vol. 3, pp. 161- 173 ,(2002) , 10.1089/109629602761624171
Philippe Montravers, Hervé Dupont, Remy Gauzit, Benoit Veber, Christian Auboyer, Patrick Blin, Christophe Hennequin, Claude Martin, Candida as a risk factor for mortality in peritonitis. Critical Care Medicine. ,vol. 34, pp. 646- 652 ,(2006) , 10.1097/01.CCM.0000201889.39443.D2