Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst
作者： S. A. Duncan , K. Manova , W. S. Chen , P. Hoodless , D. C. Weinstein
关键词: Blastocyst 、 Endoderm 、 Molecular biology 、 Embryonic stem cell 、 Organogenesis 、 Embryo 、 Yolk sac 、 Cell biology 、 Biology 、 Hepatocyte nuclear factor 4 、 Mesonephric tubules
摘要: The expression of HNF-4 (hepatocyte nuclear factor 4) mRNA in postimplantation mouse embryos was analyzed by situ hybridization. Expression found the primary endoderm at embryonic day 4.5 and restricted to columnar visceral cells yolk sac from 5.5 8.5. first detected tissues 8.5, liver diverticulum hindgut. At later times transcripts were observed mesonephric tubules, pancreas, stomach, intestine and, still later, metanephric tubules developing kidney. This pattern suggests that has a role earliest stages murine development as well organogenesis.
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