Analysis of tumor microenvironmental features to refine prognosis by T, N risk group in patients with stage III colon cancer (NCCTG N0147) (Alliance)

摘要: Background Tumor-infiltrating lymphocytes (TILs), tumor budding, and micropapillary architecture may influence growth metastatic potential, thereby enhancing prognostic stratification. We analyzed these features their relative contribution to overall outcome in low (T1–3 N1) high (T4 and/or N2) risk groups that are used inform the duration of adjuvant chemotherapy patients with resected stage III colon cancers. Patients methods Among 1532 treated a phase trial FOLFOX-based therapy, intraepithelial TIL densities, were quantified routine histopathological sections light microscopy. Optimal cut-points determined association disease-free survival (DFS) training validation sets. Associations or contributions individual combined variables DFS using multivariable Cox regression models. Results TILs, shown differ significantly by T, N mismatch repair (MMR) status. Low variable [hazard ratio = 2.07 (95% CI, 1.50% 2.88%); Padj Conclusions density budding each validated as significant provided robust stratification groups, being strongest predictor among high-risk patients. ClinicalTrials.gov Identifier NCT00079274.