Effector-triggered post-translational modifications and their role in suppression of plant immunity

作者: Andrew J. M. Howden , Edgar Huitema

DOI: 10.3389/FPLS.2012.00160

关键词: Pathogen-associated molecular patternImmune systemPattern recognition receptorPlant ImmunityEffectorNeuroscienceImmunologyBiologyImmunitySignallingProteomics

摘要: Plant-pathogen interactions feature complex signalling exchanges between host and microbes that ultimately determine association outcomes. Plants deploy Pattern Recognition Receptors (PRRs) to perceive Pathogen Associated Molecular Patterns (PAMPs), mount Triggered Immunity (PTI) fend off potential pathogens. In recent years an increasing number of defence components have been identified along with a mechanistic understanding their regulation during immune responses. Post-translational modifications (PTMs) are now thought play crucial role in regulating signalling. bid suppress PTI infect host, pathogens evolved large repertoires effectors trigger susceptibility allow colonization tissues. While great progress has made elucidating networks plants the activities suppression, critical gap exists our effector mechanism-of-action. Given importance PTMs signalling, we will explore question: how do modify post-translational status proteins thus interfere processes required for immunity? We consider emerging proteomics based experimental strategies may help us answer this important question open pathogens’ black box.

参考文章(37)
Selena Gimenez-Ibanez, Dagmar R. Hann, Vardis Ntoukakis, Elena Petutschnig, Volker Lipka, John P. Rathjen, AvrPtoB targets the LysM receptor kinase CERK1 to promote bacterial virulence on plants. Current Biology. ,vol. 19, pp. 423- 429 ,(2009) , 10.1016/J.CUB.2009.01.054
Min Gab Kim, Luis Da Cunha, Aidan J McFall, Youssef Belkhadir, Sruti DebRoy, Jeffrey L Dangl, David Mackey, None, Two Pseudomonas syringae Type III Effectors Inhibit RIN4-Regulated Basal Defense in Arabidopsis Cell. ,vol. 121, pp. 749- 759 ,(2005) , 10.1016/J.CELL.2005.03.025
Cyril Zipfel, Early molecular events in PAMP-triggered immunity. Current Opinion in Plant Biology. ,vol. 12, pp. 414- 420 ,(2009) , 10.1016/J.PBI.2009.06.003
Kinya Nomura, Sruti DebRoy, Yong Hoon Lee, Nathan Pumplin, Jonathan Jones, Sheng Yang He, A bacterial virulence protein suppresses host innate immunity to cause plant disease. Science. ,vol. 313, pp. 220- 223 ,(2006) , 10.1126/SCIENCE.1129523
Laurence S. Boutemy, Stuart R. F. King, Joe Win, Richard K. Hughes, Thomas A. Clarke, Tharin M. A. Blumenschein, Sophien Kamoun, Mark J. Banfield, Structures of Phytophthora Rxlr Effector Proteins: A Conserved But Adaptable Fold Underpins Functional Diversity. Journal of Biological Chemistry. ,vol. 286, pp. 35834- 35842 ,(2011) , 10.1074/JBC.M111.262303
Sophien Kamoun, Groovy times: filamentous pathogen effectors revealed. Current Opinion in Plant Biology. ,vol. 10, pp. 358- 365 ,(2007) , 10.1016/J.PBI.2007.04.017
Gitta Coaker, Arnold Falick, Brian Staskawicz, Activation of a Phytopathogenic Bacterial Effector Protein by a Eukaryotic Cyclophilin Science. ,vol. 308, pp. 548- 550 ,(2005) , 10.1126/SCIENCE.1108633
Sharon C. Mithoe, Paul J. Boersema, Lidija Berke, Berend Snel, Albert J. R. Heck, Frank L. H. Menke, Targeted quantitative phosphoproteomics approach for the detection of phospho-tyrosine signaling in plants. Journal of Proteome Research. ,vol. 11, pp. 438- 448 ,(2012) , 10.1021/PR200893K
Peter N. Dodds, John P. Rathjen, Plant immunity: towards an integrated view of plant–pathogen interactions Nature Reviews Genetics. ,vol. 11, pp. 539- 548 ,(2010) , 10.1038/NRG2812
IRIS J. E. STULEMEIJER, MATTHIEU H. A. J. JOOSTEN, Post-translational modification of host proteins in pathogen-triggered defence signalling in plants Molecular Plant Pathology. ,vol. 9, pp. 545- 560 ,(2008) , 10.1111/J.1364-3703.2008.00468.X