Blood thrombopoietin levels in clonal thrombocytosis and reactive thrombocytosis.

摘要: Abstract Background: Although the distinction between clonal and reactive thrombocytosis is clinically relevant because has more thrombohemorragic complications, differential diagnosis of these two entities can be difficult. Methods such as detection unstimulated erythroid or megakaryocyte colony growth are not readily available. Therefore, we measured blood thrombopoietin levels to determine whether used distinguish conditions. Patients Methods: Thrombopoietin were in 73 patients with (platelet count >500,000/μL), including 39 (20 essential thrombocythemia, 15 agnogenic myeloid metaplasia, 1 patient polycythemia vera, 3 undefined myeloproliferative disorders) 34 (17 malignant tumors, 11 inflammatory diseases, 4 sickle cell disease, 2 iron deficiency anemia). Seventeen normal volunteers controls. Results: significantly higher ( P Conclusions: may helpful distinguishing thrombocytosis. probably responsible for elevated platelet counts but High cannot explained solely by mass.