Uncovering dynamic phosphorylation signaling using mass spectrometry
作者： Hannah Johnson
DOI: 10.1016/J.IJMS.2015.08.002
关键词: Mass spectrometric 、 Chromatography 、 Mass spectrometry 、 Phosphoproteomics 、 Computational biology 、 Absolute quantification 、 Mechanism (biology) 、 Phosphorylation 、 Chemistry 、 Kinase
摘要: Abstract Dynamic phosphorylation is a critical regulatory mechanism that controls many aspects of cell biology. To gain insight into the regulation kinases in health and disease it essential to understand signaling both qualitatively quantitatively. Recent advances mass spectrometry based methods have made possible identify quantify thousands events across different cellular conditions. Furthermore, these quantitative phosphoproteomics facilitate relative, absolute quantification determination stoichiometry. This review summarizes spectrometric strategies been developed uncover describes examples driven analyses led understanding dynamics mammalian cells.
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