Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis.
作者： Kamon Sanada , Amitabh Gupta , Li-Huei Tsai
DOI: 10.1016/S0896-6273(04)00222-3
关键词: Laminar organization 、 Cortex (botany) 、 Integrin 、 Adhesion 、 Radial glial fiber 、 Mutation 、 Biology 、 Neuroscience 、 Corticogenesis 、 Phosphorylation
摘要: Abstract Disabled-1 regulates laminar organization in the developing mammalian brain. Although mutation of disabled-1 gene scrambler mice results abnormalities neuronal positioning, migratory behavior linked to signaling is not completely understood. Here we show that newborn neurons cortex remain attached process their parental radial glia during entire course migration, whereas wild-type detach from glial fiber later stage migration. This abnormal neuronal-glial adhesion highly positional abnormality and depends intrinsically on Tyr220 Tyr232, potential phosphorylation sites corticogenesis. Importantly, at those α3 integrin levels, which critical for timely detachment migrating glia. Altogether, these outline molecular mechanism by controls adhesive property glia, thereby maintaining proper positioning
elsevier.com
sci-hub.se 参考文章(47)
Bagirathy Nadarajah, Janice E. Brunstrom, Jaime Grutzendler, Rachel O. L. Wong, Alan L. Pearlman, Two modes of radial migration in early development of the cerebral cortex. Nature Neuroscience. ,vol. 4, pp. 143- 150 ,(2001) , 10.1038/83967
Stephen C. Noctor, Alexander C. Flint, Tamily A. Weissman, Ryan S. Dammerman, Arnold R. Kriegstein, Neurons derived from radial glial cells establish radial units in neocortex Nature. ,vol. 409, pp. 714- 720 ,(2001) , 10.1038/35055553
Takumi Kato, Kouji Katabami, Hironori Takatsuki, Seon Ae Han, Ken-ichi Takeuchi, Tatsuro Irimura, Tsutomu Tsuji, Characterization of the promoter for the mouse α3 integrin gene FEBS Journal. ,vol. 269, pp. 4524- 4532 ,(2002) , 10.1046/J.1432-1033.2002.03146.X
Stephen C. Noctor, Alexander C. Flint, Tamily A. Weissman, Winston S. Wong, Brian K. Clinton, Arnold R. Kriegstein, Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. The Journal of Neuroscience. ,vol. 22, pp. 3161- 3173 ,(2002) , 10.1523/JNEUROSCI.22-08-03161.2002
Brian W. Howell, Richard Hawkes, Philippe Soriano, Jonathan A. Cooper, Neuronal position in the developing brain is regulated by mouse disabled-1 Nature. ,vol. 389, pp. 733- 737 ,(1997) , 10.1038/39607
Ramin Homayouni, Dennis S. Rice, Michael Sheldon, Tom Curran, Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1 The Journal of Neuroscience. ,vol. 19, pp. 7507- 7515 ,(1999) , 10.1523/JNEUROSCI.19-17-07507.1999
Vicki Hammond, Brian Howell, Leanne Godinho, Seong-Seng Tan, disabled-1 Functions Cell Autonomously during Radial Migration and Cortical Layering of Pyramidal Neurons The Journal of Neuroscience. ,vol. 21, pp. 8798- 8808 ,(2001) , 10.1523/JNEUROSCI.21-22-08798.2001
Thomas Hiesberger, Marion Trommsdorff, Brian W Howell, Andre Goffinet, Marc C Mumby, Jonathan A Cooper, Joachim Herz, Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation Neuron. ,vol. 24, pp. 481- 489 ,(1999) , 10.1016/S0896-6273(00)80861-2
Pasko Rakic, Verne S Caviness, Cortical development: View from neurological mutants two decades later Neuron. ,vol. 14, pp. 1101- 1104 ,(1995) , 10.1016/0896-6273(95)90258-9
Verne S. Caviness, Neocortical histogenesis in normal and reeler mice: a developmental study based upon [3H]thymidine autoradiography. Developmental Brain Research. ,vol. 4, pp. 293- 302 ,(1982) , 10.1016/0165-3806(82)90141-9