Perfusion MR imaging of extracranial tumor angiogenesis.

摘要: Dynamic contrast-enhanced MRI (DCE-MRI) using small molecular weight gadolinium chelates enables noninvasive imaging characterization of tissue vascularity. Depending on the technique used, data reflecting perfusion (blood flow, blood volume, mean transit time), microvessel permeability surface area product, and extracellular leakage space can be obtained. Insights into these physiological processes obtained from inspection kinetic enhancement curves or by application complex compartmental modeling techniques. Combining morphologic features increase accuracy clinical diagnoses. Potential applications include screening for malignant disease, lesion characterization, monitoring response to treatment, assessment residual disease. Newer prognostication, pharmacodynamic assessments antivascular anticancer drugs, predicting efficacy treatment. For dynamic enter widespread practice, it will necessary develop standardized approaches measurement robust analysis approaches.