Regulator of G protein-signaling proteins and addictive drugs.
作者： John Traynor
DOI: 10.1111/J.1749-6632.2009.05150.X
关键词: Protein family 、 Dopamine receptor 、 Cell biology 、 RGS Proteins 、 Addiction 、 Regulator of G protein signaling 、 Neuroscience 、 Cell signaling 、 RGS17 、 G protein 、 Biology
摘要: Regulator of G protein-signaling (RGS) proteins are a family more than 30 intracellular that negatively modulate signaling receptors in the protein-coupled receptor family. This includes for opioids, cannabinoids, and dopamine mediate acute effects addictive drugs or behaviors chronic leading to development disease. Members RGS protein family, by modulating signaling, influence processes lead addiction. In turn, control expression levels several proteins. review will consider distribution mechanisms action proteins, particularly R4 R7 families have been implicated actions drugs, how knowledge these is contributing an understanding processes, whether specific could provide targets medications manage and/or treat
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