Effect of Glucagon on Meal-Induced Gastric Secretion in Man
作者： Stanisław J. Konturek , Jerzy Biernat , Nina Kwiecień , Jan Oleksy
DOI: 10.1016/S0016-5085(75)80081-3
关键词: Histamine 、 Pentagastrin 、 Gastric acid 、 Internal medicine 、 Chemistry 、 Endocrinology 、 Dose–response relationship 、 Secretion 、 Radioimmunoassay 、 Glucagon 、 Pepsin
摘要: The effect of glucagon on gastric acid and pepsin secretion, basal or stimulated by a meal, pentagastrin histamine, was studied in duodenal ulcer patients. Intravenous infused graded doses ranging from 6.2 to 50 μg per kg-hr produced dose-related inhibition pentagastrin-induced secretion reaching about 40% the control level at dose kg-hr. Acid paralleled decrease output serum calcium accompanied rise blood glucose concentration. Glucagon used standard 25 50% induced meal (measured intragastric titration) significant gastrin measured radioimmunoassay. Histamine-induced only slightly inhibited glucagon, degree for (25%) (20%) statistically insignificant.
gastrojournal.org
sci-hub.st 参考文章(14)
Rosalyn S. Yalow, Solomon A. Berson, Radioimmunoassay of gastrin Gastroenterology. ,vol. 58, pp. 1- 14 ,(1970) , 10.1016/S0016-5085(70)80086-5
AKIO KANETO, YOSHIATSU MIZUNO, YOSHIMASA TASAKA, KINORI KOSAKA, Stimulation of glucagon secretion by tetragastrin. Endocrinology. ,vol. 86, pp. 1175- 1180 ,(1970) , 10.1210/ENDO-86-5-1175
A. G. Melrose, Effect of Glucagon on Gastric Secretion in Man. Gut. ,vol. 1, pp. 142- 145 ,(1960) , 10.1136/GUT.1.2.142
M. G. Korman, C. Soveny, J. Hansky, The effect of glucagon on serum gastrin: II Studies in pernicious anaemia and the Zollinger-Ellison syndrome Gut. ,vol. 14, pp. 459- 461 ,(1973) , 10.1136/GUT.14.6.459
J. Hansky, C. Soveny, M. G. Korman, The effect of glucagon on serum gastrin. I. Studies in normal subjects. Gut. ,vol. 14, pp. 457- 458 ,(1973) , 10.1136/GUT.14.6.457
Johan Iversen, Secretion of glucagon from the isolated, perfused canine pancreas Journal of Clinical Investigation. ,vol. 50, pp. 2123- 2136 ,(1971) , 10.1172/JCI106706
Roger H. Unger, Hermann Ketterer, John Dupré, Anna M. Eisentraut, The Effects of Secretin, Pancreozymin, and Gastrin on Insulin and Glucagon Secretion in Anesthetized Dogs * Journal of Clinical Investigation. ,vol. 46, pp. 630- 645 ,(1967) , 10.1172/JCI105565
M. L. Anson, THE ESTIMATION OF PEPSIN, TRYPSIN, PAPAIN, AND CATHEPSIN WITH HEMOGLOBIN. The Journal of General Physiology. ,vol. 22, pp. 79- 89 ,(1938) , 10.1085/JGP.22.1.79
John S. Fordtran, John H. Walsh, Gastric Acid Secretion Rate and Buffer Content of the Stomach after Eating. RESULTS IN NORMAL SUBJECTS AND IN PATIENTS WITH DUODENAL ULCER Journal of Clinical Investigation. ,vol. 52, pp. 645- 657 ,(1973) , 10.1172/JCI107226
G. Dotevall, N. G. Kock, A. Walan, Inhibition of Pentagastrin-induced Gastric Acid Secretion in Man by Glucagon Given Intravenously Scandinavian Journal of Gastroenterology. ,vol. 4, pp. 713- 716 ,(1969) , 10.3109/00365526909180658