Cytokine-mediated regulation of transferrin synthesis in mouse macrophages and human T lymphocytes
作者： A Djeha , JL Perez-Arellano , SL Hayes , R Oria , RJ Simpson
DOI: 10.1182/BLOOD.V85.4.1036.BLOODJOURNAL8541036
关键词: Immunology 、 Molecular biology 、 Cytokine 、 Paracrine signalling 、 Transferrin 、 Tumor necrosis factor alpha 、 Cell culture 、 Macrophage 、 Autocrine signalling 、 Biology 、 T lymphocyte
摘要: Transferrin (Tf) plays an important role during immunologic activation by donating iron to activated lymphocytes. Therefore, synthesis lymphomyeloid cells has been investigated. Mouse macrophages and macrophage cell lines synthesized Tf, with levels being markedly increased gamma-interferon (gamma-IFN) and, a lesser extent, interleukin-1 beta (IL-1 beta), IL-6, tumor necrosis factor alpha (TNF alpha). Tf was also produced phytohemagglutinin-stimulated human T two T-cell IL-2. Even after appropriate activation, none or monocytic mouse cells, lines, thymus cells. In both species, B-lineage were negative. synthesised from congenitally hypotransferrinemic mice responsive gamma-IFN, but lower than those normal controls. Synthesis murine hepatoma IL-6 unaffected IL-1, TNF alpha, gamma-IFN. Iron decreased had no effect on the mRNA paralleled protein synthesis, suggesting that regulation pre-translational. Thus, is regulated differently hepatic which consistent suggestion may act in paracrine (mouse) autocrine (human) manner
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