MicroRNA-106b~25 expressions in tumor tissues and plasma of patients with gastric cancers
作者： Rupeng Zhang , Weijia Wang , Fangxuan Li , Hui Zhang , Juntian Liu
DOI: 10.1007/S12032-014-0243-X
关键词: Biology 、 Real-time polymerase chain reaction 、 Pathology 、 Pathological 、 Biomarker (medicine) 、 Stage (cooking) 、 Lymph node 、 Cancer 、 Internal medicine 、 Hematology 、 microRNA
摘要: MiR-106b~25 has been researched in several cancers. The aim of this study was to test miR-106b~25 expressions 40 operative specimens and 20 pre-operative plasma samples GC patients explore the correlations between these miRNAs some related clinical pathological factors. Compared with corresponding adjacent non-tumorous tissues, expression cluster increased significantly gastric cancer tissues from samples, a median relative 2.41(miR-106b), 2.83(miR-93) 2.71(miR-25). miRNA-106b~25 tumor correlated size, borrmann type, depth invasion (T), lymph node metastases (N), distant metastasis (M) TNM stage (P<0.05). expressive level also statistically significant higher than healthy volunteers plasma, 2.51(miR-106b), 2.32(miR-93) 2.10(miR-25). type (P<0.05) patients. What's more, three components expressed consistently at high both plasma. Considering relationship factors (TNM stage), it implied that could be next potential biomarker for diagnosis predictive prognosis
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