Overexpressed transcription factor FOXM1 contributes to the progression of colorectal cancer.
作者： HONGMEI ZHANG , HUA ZHONG , LEI LI , WANSHENG JI , XIAOQIAN ZHANG
关键词: Molecular medicine 、 Cancer research 、 Molecular biology 、 FOXM1 、 Cell culture 、 Cell cycle 、 Oncogene 、 Biology 、 Cancer 、 Colorectal cancer 、 Immunohistochemistry
摘要: Forkhead box M1 (FOXM1) is a characteristic proliferation‑associated transcription factor, which overexpressed in various types of human cancer. The aim the present study was to determine expression FOXM1 large collection colorectal cancer (CRC) samples. Between March 2012 and January 2014, 96 patients with histologically diagnosed CRC were recruited into current study. Using immunohistochemistry, reverse transcription‑quantitative polymerase chain reaction western blotting, mRNA protein levels tissue samples determined. function cells evaluated by small interfering RNA‑mediated depletion FOXM1, followed analyses cell proliferation invasion. High staining for observed significantly more samples: 85.42% (82/96) compared 18.75% (18/96) adjacent normal mucosa Silencing inhibited LoVo cells, express relatively high level invasion migration also markedly suppressed. data from suggested that pathogenesis may be mediated inhibition provide promising therapeutic strategy CRC.
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