Strategic Infarct Dementia: Clinical Features, Neuroimaging and Neuropsychological Findings

摘要: Background: Strategic infarct dementia (SID) is characterized by focal ischemic lesions involving specific sites that are critical for higher cortical functions. However, the mechanisms of SID not well understood. We evaluated lesion sites, neuropsychiatric symptoms, neuroimaging and neuropsychological findings in patients with have come up suggestions mechanism behind SID. Methods: Eleven according to NINDSAIREN criteria vascular were included. All given a neurologic examination, brain MRI MRA perfusion SPECT using Tc-99m HMPAO. symptoms status Korean-version Neuropsychiatric Inventory(K-NPI) Seoul Neuropsychological Screening Battery. Results: Various responsible SID; thalamus (n=5), genu internal capsule (n=2), temporooccipital lobe medial temporal (n=1), frontal (n=1). The most common symptom was apathy K-NPI. Brain revealed ipsilateral hypoperfusion, mainly areas. In several cases, there some degrees hypoperfusion contralateral areas lesion. On assessment, cognitive deficits on attention executive function prominent. Conclusions: thalamus, capsule, area Based results subcortical strategic prominent function, it suggested disruption frontal-subcortical circuit may play an important role