Dietary (n-3) fat and cholesterol alter tissue antioxidant enzymes and susceptibility to oxidation in SHR and WKY rats.

摘要: Previously, 8% fish oil blend diets, compared to butter and soybean reduced specific antioxidant enzyme activities tissue susceptibility in vitro oxidative stress spontaneously hypertensive (SHR) Wistar Kyoto (WKY) rats. Moreover, high cholesterol (5.0 g/kg diet) diets protected against lipid oxidation. In this study, we hypothesized that 160 g fat/kg diet as blends of (n-6) or (n-3) oils would alter thus increase The effects saturated (butter, B), (soybean oil, SBO) (menhaden MO) with (0.5 5.0 g/kg) on systolic blood pressure (SBP), plasma lipids, enzymes oxidation were examined SHR WKY SBP at 13 wk age was greater (P < 0.001) than rats, but not affected by diets. Plasma triacylglycerols decreased MO Hepatic glutathione reductase SBO-fed enhanced SBO- MO-fed Glutathione levels RBC livers Lipid red cells (RBC) from SBO groups, hearts groups. High = peroxidation liver Greater amounts dietary fat enhance oxidation, which can be modulated increased