Hypolipidemic effects of Solidago chilensis hydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

摘要: AbstractContext: Despite several studies on the effects of Solidago chilensis Meyen (Asteraceae), phytochemical and hypolipidemic properties remain underappreciated.Objective: This study evaluates antioxidant hydroalcoholic extract (HE) quercetrin from S. aerial parts in cholesterol-fed rats.Materials methods: The HE was analyzed by high-performance liquid chromatography, followed isolation. Hypercholesterolemic rats (1% cholesterol 0.5% cholic acid for 15 d) were treated with (150, 300, 600 mg/kg p.o.; n = 6), simvastatin (4 mg/kg or (10 mg/kg n = 6) once a day 30 d. During this period, high-cholesterol diet maintained until 30th treatment.Results: Rats 600 mg/kg) showed decreased serum levels total (−19.9, −27.5, −31.0, −39.4%), lipoprotein-cholesterol (−36.0, −37.5, −43.3, −59.4%), triacylglycerides (...