Cognitive rehabilitation of working memory in juvenile multiple sclerosis-effects on cognitive functioning, functional MRI and network related connectivity.
作者： Martina Hubacher , John DeLuca , Peter Weber , Maja Steinlin , Ludwig Kappos
DOI: 10.3233/RNN-150497
关键词: Multiple sclerosis 、 Alertness 、 Working memory 、 Cognition 、 Juvenile 、 Cognitive psychology 、 Audiology 、 Psychology 、 Cognitive rehabilitation therapy 、 Cognitive skill 、 Effects of sleep deprivation on cognitive performance
摘要: PURPOSE To assess possible effects of working memory (WM) training on cognitive functionality, functional MRI and brain connectivity in patients with juvenile MS. METHODS Cognitive status, fMRI inter-network were assessed 5 cases MS aged between 12 18 years. Afterwards they received a computerized WM for four weeks. Primary outcome measures (visual verbal) alertness. Activation patterns related to during using an N-Back task increasing difficulty. Inter-network analyses focused fronto-parietal (left right), default-mode (dorsal ventral) the anterior salience network. Cognitive functioning, reassessed directly after again nine months following training. RESULTS Response treatment was seen two patients. These showed increased performance alertness training. behavioural changes accompanied by network activation systematic connectivity. The remaining participants non-responders treatment. Effects maintained up training, whereas observed disappeared. CONCLUSIONS Responders revealed all applied measures. Disease activity general intelligence may be factors associated response
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