Effects of rosiglitazone on postprandial leukocytes and cytokines in type 2 diabetes.
作者： J.P.H. van Wijk , M. Castro Cabezas , B. Coll , J. Joven , T.J. Rabelink
DOI: 10.1016/J.ATHEROSCLEROSIS.2005.07.001
关键词: Postprandial 、 Interleukin 6 、 Lymphocyte 、 Inflammation 、 Endocrinology 、 Cytokine 、 Medicine 、 Type 2 diabetes 、 Internal medicine 、 Chemokine 、 Rosiglitazone
摘要: Abstract Objective We postulated that in type 2 diabetes, the postprandial phase is a pro-inflammatory state can be modulated by PPAR-γ agonists. For this purpose, we determined effects of rosiglitazone (8mg/d) on leukocyte counts and cytokines (IL-6 IL-8) patients with diabetes. Methods results A randomized, 8-week, cross-over, placebo-controlled, double-blind clinical trial was performed 19 Standardized 6-h oral fat-loading tests were after each treatment period. During placebo treatment, blood leukocytes increased to maximum postprandially, due significant increases neutrophils lymphocytes. Concomitant observed for IL-6 IL-8, major chemokines responsible recruitment. Rosiglitazone reduced incremental area under curves (dAUCs) (−63%, p Conclusions attenuated neutrophils, IL-8 Since inflammation force driving atherosclerosis, man lives period most part day, inflammatory response meal may delay progression atherosclerosis. Condensed abstract These contribute cardiovascular risk reduction.
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