Prostaglandin D2 inhibits pentylenetetrazole-induced convulsions in rats by a serotonin-mediated mechanism.
作者： Salil K. Bhattacharya , Surendra S. Parmar
关键词: Metergoline 、 Anticonvulsant 、 Quipazine 、 Serotonergic 、 Chemistry 、 Pharmacology 、 Internal medicine 、 Mechanism of action 、 Serotonin 、 Convulsion 、 Neurotoxin 、 Endocrinology
摘要: Prostaglandins (PGs) of the E series are known to exert anticonvulsant action in experimental animals. Earlier studies from this laboratory have indicated that PGE1 inhibits pentylenetetrazole (PTZ)-induced convulsions rats through a serotonin-mediated mechanism. PGD2, major PG rodent brain, shares number central pharmacological actions PGEs, and like latter it potentiates phenobarbitone phenytoin rats. The present study was undertaken investigate putative PGD2 against PTZ-induced evaluate role serotonin PGD2. (5, 10, 20 µg, icv) produced dose-related inhibition clonic (20 significantly attenuated following pretreatment with pharmacologic agents reduce serotonergic activity, including 5,6-dihydroxytryptamine, selective neurotoxin for neurons, p-chlorophenylalanine, specific inhibitor biosynthesis, metergoline, postsynaptic receptor antagonist, quipazine, which is inhibit neuronal release serotonin. These findings, conjunction an earlier indicating augments rat brain suggest activity mediated
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