Prostaglandin D(2) is crucial for seizure suppression and postictal sleep.

摘要: Epilepsy is a neurological disorder with the occurrence of seizures, which are often accompanied by sleep. Prostaglandin (PG) D2 produced hematopoietic or lipocalin-type PGD synthase (H- L-PGDS) and involved in regulation physiological Here, we show that H-PGDS, L/H-PGDS DP1 receptor (DP1R) KO mice exhibited more intense pentylenetetrazole (PTZ)-induced seizures terms latency seizure onset, duration generalized tonic-clonic number spikes. Seizures significantly increased PGD2 content brain wild-type mice. This PTZ-induced increase was attenuated brains L- H-PGDS abolished Postictal non-rapid eye movement sleep observed DP2R KO, but not L-, DP1R These findings demonstrate acting on essential for suppression L-PGDS/PGD2/DP1R system regulates follows seizures.