Prevalence, morphology, and prognosis of human papillomavirus in tonsillar cancer.

摘要: Objectives: We sought to identify the prevalence of human papillomavirus (HPV) in tonsillar squamous cell carcinoma, and examine relationship HPV prognosis tumor morphology. Methods: performed situ hybridization for retrospective clinical outcome analysis. Results: Of 48 patients with identified 35% as HPV-positive tumors. Age-matched controls had no evidence HPV. There was significant difference between HPV-negative regarding age (p = 0.34), tobacco consumption 0.59), alcohol 0.91), or treatment method 0.39). Forty-four were eligible The overall rate recurrence this population 25%, disease-specific survival 84%. two groups either incidence 0.14) 0.19). HPV-associated tumors developed from crypts significantly more frequently than did 0.01). Conclusions: As previously described, is associated carcinoma tonsil; however, status our series not correlate outcome. Morphologically, we found that their origin crypts, whereas arose surface epithelium.