Synthesis of (3- tert -Butylpyrazolo[5,1- c ][1,2,4]triazin-4-yl)phosphine Oxides
作者： L. M. Mironovich , N. G. Kolotyrkina , M. E. Minyaev , S. M. Ivanov , S. M. Ivanov
DOI: 10.1134/S1070428021010073
关键词: Mass spectrum 、 Lower temperature 、 Medicinal chemistry 、 Chemistry 、 Atmospheric oxygen 、 Phosphine 、 Nucleophilic addition 、 Lithium
摘要: Aromatic 7-R1-8-R2-3-tert-butylpyrazolo[5,1-c][1,2,4]triazines (R1 = H, Br; R2 Me, Br) reacted with lithium diphenyl- and methyl(phenyl)phosphides in THF at lower temperature to give nucleophilic addition products the C4 atom. Further oxidation atmospheric oxygen or N-bromosuccinimide afforded previously unknown (3-tert-butylpyrazolo[5,1-c][1,2,4]triazin-4-yl)phosphine oxides 2,2-dibromoacetamide as a by-product. The structure of isolated compounds was confirmed by IR, 1H, 13C, 31P NMR, mass spectra X-ray analysis.
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