Treatment of palmar hyperhidrosis with botulinum toxin type A: results of a pilot study based on a novel injective approach

摘要: Botulinum toxin type A (BoNT/A) improves symptoms of palmar hyperhidrosis, but some drawbacks related to its injection in the hands still persist (e.g., muscle weakness caused by drug diffusion, pain during injections, or delayed functional recovery hand when using wrist block). In this open, controlled, non-randomized, intra-individual clinical trial, 50 patients with severe hyperhidrosis received same session intradermal injections BoNT/A through a new technique (NA/BoNT/A) based on use specific adapter for needles (PCT/IT2011/000299) one hand, and following anaesthetic block (WB/BoNT/A) other. Several measures efficacy safety were evaluated both before (T0) four weeks after treatment (T4): disease severity improvement, sweat reduction, handgrip strength decrease, pain/discomfort treatment, patient's global satisfaction. All also re-evaluated gravimetric assessment production at T12 T24 compare long-term two treatments. responsive treatments, was significantly decreased T4 compared baseline (p < 0.0001). Both procedures equally effective reducing short term (p = 0.08 T4), WB/BoNT/A higher decrease Finally, reported that NA/BoNT/A comparable (p = 0.204); however, they globally more satisfied rather than method No significant difference percentage relapse detected between treated via (p = 0.70). The described inject seems lead clinicians obtain therapeutic results conventional wrist. Moreover, injective approach increase extent is preferred mostly because it makes faster.