Impact of Diabetes on Cardiovascular Outcomes in Hemodialysis Patients Undergoing Coronary Revascularization

作者: Masahiro Natsuaki , Yutaka Furukawa , Takeshi Morimoto , Yoshihisa Nakagawa , Masaharu Akao

DOI: 10.1253/CIRCJ.CJ-10-1235

关键词:

摘要: Background: Among hemodialysis (HD) patients, those who have diabetes poorer cardiovascular outcomes than non-diabetic but the impact of on has not been fully elucidated in HD patients undergoing coronary revascularization. Methods and Results: We identified 375 (203 diabetes, 172 non-diabetes) 9,006 without (3,455 5,551 database CREDO-Kyoto registry their first In non-HD significantly higher risks death (10.8% vs. 7.7%, P<0.0001; adjusted hazard ratio (HR) 1.29, P<0.0001) major adverse events (MACE), a composite death, myocardial infarction stroke (18.8% 13.3%, HR 1.36, were seen diabetic through 4-year follow-up. Analysis showed that duration before revascularization was shorter (median interval: 858 2,216 days, P<0.0001). contrast to results (41.9% 39.1%, P=0.75; 0.98, P=0.93) MACE (45.6% 45.8%, P=0.83; 0.87, P=0.50) after comparable between patients. There significant interactions for MACE. Conclusions: require extremely poor irrespective concomitant diabetes. (Circ J 2011; 75: 1616-1625)

参考文章(26)
Bernardo Stein, William S. Weintraub, Suzanne S.P. Gebhart, Caryn L. Cohen-Bernstein, Ralph Grosswald, Henry A. Liberman, John S. Douglas, Douglas C. Morris, Spencer B. King, Influence of Diabetes Mellitus on Early and Late Outcome After Percutaneous Transluminal Coronary Angioplasty Circulation. ,vol. 91, pp. 979- 989 ,(1995) , 10.1161/01.CIR.91.4.979
Mitchell J Magee, Todd M Dewey, Tea Acuff, James R Edgerton, James F Hebeler, Syma L Prince, Michael J Mack, Influence of diabetes on mortality and morbidity: off-pump coronary artery bypass grafting versus coronary artery bypass grafting with cardiopulmonary bypass The Annals of Thoracic Surgery. ,vol. 72, pp. 776- 781 ,(2001) , 10.1016/S0003-4975(01)02840-5
Alfred K. Cheung, Mark J. Sarnak, Guofen Yan, Johanna T. Dwyer, Robert J. Heyka, Michael V. Rocco, Brendan P. Teehan, Andrew S. Levey, Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients Kidney International. ,vol. 58, pp. 353- 362 ,(2000) , 10.1046/J.1523-1755.2000.00173.X
Claude Le Feuvre, Maria Borentain, Farzin Beygui, Gérard Helft, Jean Paul Batisse, Jean Philippe Metzger, Comparison of short- and long-term outcomes of coronary angioplasty in patients with and without diabetes mellitus and with and without hemodialysis. American Journal of Cardiology. ,vol. 92, pp. 721- 725 ,(2003) , 10.1016/S0002-9149(03)00838-5
Shizu Oyamada, Junjiro Kobayashi, Osamu Tagusari, Hiroyuki Nakajima, Satoko Nakamura, Toshikatsu Yagihara, Soichiro Kitamura, Is diabetic nephropathy a predicted risk factor?--Kaplan-Meier and multivariate analysis of confounding risk factors in off-pump coronary artery bypass grafting for chronic dialysis patients. Japanese Circulation Journal-english Edition. ,vol. 73, pp. 2056- 2060 ,(2009) , 10.1253/CIRCJ.CJ-09-0257
R. Dikow, Cardiovascular complications in the diabetic patient with renal disease: an update in 2003 Nephrology Dialysis Transplantation. ,vol. 18, pp. 1993- 1998 ,(2003) , 10.1093/NDT/GFG253
Yasuyuki Hosoda, Taira Yamamoto, Kenji Takazawa, Motoshige Yamasaki, Shin Yamamoto, Ichiro Hayashi, Kazunori Kudoh, Coronary artery bypass grafting in patients on chronic hemodialysis: surgical outcome in diabetic nephropathy versus nondiabetic nephropathy patients. The Annals of Thoracic Surgery. ,vol. 71, pp. 543- 548 ,(2001) , 10.1016/S0003-4975(00)02044-0
R. N. Foley, B. F. Culleton, P. S. Parfrey, J. D. Harriett, G. M. Kent, D. C. Murray, Paul E. Barre, Cardiac disease in diabetic end-stage renal disease Diabetologia. ,vol. 40, pp. 1307- 1312 ,(1997) , 10.1007/S001250050825
T. Kimura, T. Morimoto, Y. Furukawa, Y. Nakagawa, S. Shizuta, N. Ehara, R. Taniguchi, T. Doi, K. Nishiyama, N. Ozasa, N. Saito, K. Hoshino, H. Mitsuoka, M. Abe, M. Toma, T. Tamura, Y. Haruna, Y. Imai, S. Teramukai, M. Fukushima, T. Kita, Long-term outcomes of coronary-artery bypass graft surgery versus percutaneous coronary intervention for multivessel coronary artery disease in the bare-metal stent era. Circulation. ,vol. 118, ,(2008) , 10.1161/CIRCULATIONAHA.107.735902