Comprehensive MR Imaging Protocol for Stroke Management: Tissue Sodium Concentration as a Measure of Tissue Viability in Nonhuman Primate Studies and in Clinical Studies

摘要: PURPOSE: To investigate sodium magnetic resonance (MR) imaging for monitoring tissue viability in stroke. MATERIALS AND METHODS: A comprehensive MR protocol used to measure apparent diffusion coefficient and perfusion parameters was extended include imaging. Tissue concentration estimated by using a two-compartment model. This lasted less than 45 minutes. These were followed over the first 6 hours nonhuman primate model (n = 2) of acute embolic stroke without or with thrombolytic therapy. patients whom (<24 hours, n 11) nonacute (≥24 31) ultimately confirmed. RESULTS: The animal showed abnormal lesion immediately after embolization, these remained hours. increased time (5.7 mmol/L/h) unless halted Regions concentrations 70 mmol/L histochemi...