Extracranial Vertebral Artery Involvement in Neurofibromatosis Type I: Report of Four Cases and Literature Review

摘要: Neurofibromatosis type 1 (NF-1) is one of the most common inherited diseases and as an autosomal dominant genetic disorder results from NF-1 gene mutation with 100% penetration wide phenotypic variability. The disease can involve a variety tissues derived all three embryonic layers. vasculopathy has been described primarily in peripheral arteries, but arteries supplying CNS may also be involved. Of those, extracranial vertebral involvement commonest important. A series four patients vascular artery review pathophysiology, phenotypes, their management pertinent literature.