Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma
作者： Shan-Shan Sun , Xuan Zhou , Yuan-Yuan Huang , Ling-Ping Kong , Mei Mei
DOI: 10.1186/S12943-015-0487-X
关键词:
摘要: Background Abnormal activation of STAT3 and miR-21 plays a vital role in progression invasion solid tumors. The cyclin-dependent kinase 5 (CDK5) is reported to contribute cancer metastasis by regulating epithelial-mesenchymal transition (EMT). However, the STAT3/miR-21 axis CDK5 head neck squamous cell carcinoma remains unclear.
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