Palladium-Catalyzed Intramolecular C(sp2)-H Imidoylation for the Synthesis of Six-Membered N-Heterocycles
作者： Jing Li , Yimiao He , Shuang Luo , Jian Lei , Jian Wang
DOI: 10.1021/JO502731N
关键词:
摘要: A new strategy for the construction of phenanthridine and isoquinoline scaffolds, starting from arenes containing a pending isocyanide moiety under palladium catalysis, has been developed. This process involves sequential intermolecular insertion to an aryl palladium(II) intermediate intramolecular aromatic C–H activation as key steps. Alkyl lacking β-hydrogen is also applicable this reaction, generating unique bisheterocyclic scaffolds with three C–C bonds being formed consecutively.
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