Genome-wide association scan for variants associated with early-onset prostate cancer.
作者： Ethan M Lange , Anna M Johnson , Yunfei Wang , Kimberly A Zuhlke , Yurong Lu
DOI: 10.1371/JOURNAL.PONE.0093436
关键词:
摘要: Prostate cancer is the most common non-skin and second leading cause of related mortality for men in United States. There strong empirical epidemiological evidence supporting a stronger role genetics early-onset prostate cancer. We performed genome-wide association scan Novel aspects this study include focus on disease (defined as with diagnosed before age 56 years) use publically available control genotype data from previous studies. found significant (p<5×10−8) variants at 8q24 11p15 supportive number previously reported loci. little individual or systematic inflated findings resulting using public controls, demonstrating utility large-scale genetic studies variants. Taken together, these results demonstrate importance established power including cases
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