Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men

摘要: Background: Obesity is prevalent in PR and has been associated with prostate cancer (PCa) mortality aggressiveness. Polymorphisms (SNPs) rs9930506 rs9939609 the FTO gene have both obesity PCa. The aim of this work was to ascertain whether presence these SNPs PCa risk severity a cohort Puerto Rican men. Methods findings: study population consisted 513 men age ranging from 40-79 years old who underwent radical prostatectomy (RP) as first treatment for 128 healthy old. Genomic DNA (gDNA) extracted were determined by Real-Time PCR. defined based on RP stage Gleason Score. relationship demographic, clinical characteristics, status assessed. Logistic regression models 95% confidence interval (CI) interaction odds ratio (ORs). Results discussion: BMI, PSA considered confounders. Hardy-Weinberg equilibrium present SNPs. heterozygous forms (A/G; T/A) most genotypes frequency alleles agreed those published 1000 genomes. Results suggest an inverse association between mutated having (OR: 0.53, CI: 0.31-0.92) positive overweight 1.05, 0.68-1.62). Importantly, among cases that overweight, had greater chance high 1.39, 0.84-2.32) although results not statistical significant upon adjustment. Limitations relatively small lack access weight history all our subjects. Conclusion: offer research line be followed expanded number subjects may provide better significance, unravel rate population..