Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRL/lpr mice
作者： Hitoshi Hasegawa , Atsushi Inoue , Masatake Muraoka , Jun Yamanouchi , Tatsuhiko Miyazaki
DOI: 10.1186/AR2122
关键词:
摘要: Adoptive transfer of CD4+CD25+ regulatory T cells has been shown to have therapeutic effects in animal models autoimmune diseases. Chemokines play an important role the development diseases and humans. The present study was performed investigate whether progression organ-specific could be reduced more markedly by accumulating chemokine receptor-expressing efficiently target organs MRL/MpJ-lpr/lpr (MRL/lpr) mice. CD4+CD25+Foxp3+ (Treg cells) CCR2-transfected (CCR2-Treg were transferred via retro-orbital injection into 12-week-old MRL/lpr mice at early stage pneumonitis sialadenitis, pathological changes evaluated. Expression monocyte chemoattractant protein-1 (MCP-1)/CCL2 observed lung submandibular gland increased age-dependently. level CCR2 expression MCP-1 chemotactic activity CCR2-Treg much higher than those Treg cells. which had showed significantly sialadenitis comparison with that received This due pronounced migration their localization for a longer time MCP-1-expressing gland, resulting stronger suppressive activity. We prepared demonstrated ability ameliorate disease organs. method may provide new approach antigens remain undefined.
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