Targeting MMP-2 to treat ischemic heart injury

作者: Bryan G. Hughes , Richard Schulz

DOI: 10.1007/S00395-014-0424-Y

关键词:

摘要: Matrix metalloproteinase (MMPs) are long understood to be involved in remodeling of the extracellular matrix. However, over past decade, it has become clear that one most ubiquitous MMPs, MMP-2, numerous intracellular targets cardiac myocytes. Notably, MMP-2 proteolyzes components sarcomere, and its activity contributes ischemia-reperfusion injury heart. Together with well documented role played by MMPs myocardial occurs following infarction, this led great interest targeting treat ischemic injury. In review we will describe expanding understanding biology, how knowledge may lead improved treatments for heart We also critically preclinical studies investigating effects MMP inhibition animal models infarction injury, as recent clinical trials part effort translate these results into practice. Acknowledging disappointing inhibitors other diseases, discuss need carefully designed avoid mistakes have been previously made. conclude particular shows promise a therapy prevent progression from failure. is critical full breadth biology taken account such therapies developed.

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