Anergy and Other Immunologic Perturbances in Mycobacterial Infections

摘要: The clinical and histologic features of any infectious disease are the result not only toxic invasive properties pathogen but immune reactions host as well. In most cases, host-immune response leads to a reaction that rapidly eliminates pathogen, in other cases mechanisms fail outcome infection is fatal one. still engage long drawn-out conflict becomes chronic. Alternatively, may be abnormal or exaggerated damage more than invader. case mycobacteria, it cell-mediated (CMI) rather production antibody appears importance overcoming infections. Undoubtedly, antibodies produced naturally occurring experimental mycobacterial infections, there no evidence they play role defense. Indeed, some serum factors (possibly antibody) have harmful effects, through antibody-dependent immunopathology1 by enhancing growth challenging mycobacteria.2