5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use
作者： Thomas Dineen , Vinod F. Patel , Matthew Weiss , Ryan White , Xiao Mei Zheng
DOI:
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摘要: The present invention provides a new class of compounds useful for the modulation beta-secretase enzyme (BACE) activity. have general Formula (I); wherein variables A1, A3, A4, A5, A6, A8, R2, R7, X and Y (I) are defined herein. also pharmaceutical compositions comprising compounds, corresponding uses treatment disorders and/or conditions related to A-beta plaque formation deposition, resulting from biological activity BACE. Such BACE mediated include, example, Alzheimer's Disease, cognitive deficits, impairments, schizophrenia other central nervous system conditions. further Formulas (II) sub-formula embodiments (II), intermediates processes methods preparation (I)-(II).
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