Novel 2-amino-5, 5-diaryl-imidazol-4-ones
作者： Laszlo Rakos , Katharina Högdin , Sofia Karlström , Stefan Berg , Jesper Hallberg
DOI:
关键词:
摘要: This invention relates to novel compounds having the structural formula (I) below: and their pharmaceutically acceptable salt, compositions methods of use. These provide a treatment or prophylaxis cognitive impairment, Alzheimer Disease, neurodegeneration dementia.
lens.org 参考文章(6)
Dominick Anthony Quagliato, Albert Jean Robichaud, Yanfang Li, Michael Sotirios Malamas, Ping Zhou, Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation ,(2006)
Eric Steven Manas, Yanfang Li, Yinfa Yan, Yi Fan, Pawel Wojciech Nowak, Derek Cecil Cole, Ronald Charles Bernotas, Ping Zhou, 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION ,(2006)
Dominick A. Quagliato, Michael Sotirios Malamas, James Joseph Erdei, Yinfa Yan, Iwan Suwandi Gunawan, Ping Zhou, Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase ,(2005)
Dominick Anthony Quagliato, Albert Jean Robichaud, Schuyler Adam Antane, Michael Sotirios Malamas, James Joseph Erdei, William Floyd Fobare, Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace) ,(2006)
Ulrich Iserloh, Brian McKittrick, William J. Greenlee, Thuy X. H. Le, Suresh D. Babu, Andrew W. Stamford, Johannes H. Voigt, Yusheng Wu, Elizabeth M. Smith, Michelle L. Morris, Zhong-Yue Sun, Dawit Tadesse, John P. Caldwell, Lingyan Wang, Yuanzan C. Ye, Kurt W. Saionz, Tao Guo, Jared N. Cumming, Robert D. Mazzola, Corey Strickland, Huizhong Gu, Rachael C. Hunter, Gang Qian, Zhaoning Zhu, Heterocyclic aspartyl protease inhibitors ,(2005)
Gianni Chessari, Katharina Hogdin, Christopher Murray, Johan Hedstrom, Miles Stuart Congreve, Jacob Kihlstrom, Jeremy Burrows, Stefan Berg, Sven Hellberg, Karin Kolmodin, Sahil Patel, Johan Lindstrom, Novel 2-amino-imidazole-4-one compounds and their use in the manufacture of a medicament to be used in the treatment of cognitive impairment, alzheimer’s disease, neurodegeneration and dementia. ,(2006)