2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION

作者: Eric Steven Manas , Yanfang Li , Yinfa Yan , Yi Fan , Pawel Wojciech Nowak

DOI:

关键词:

摘要: The present invention provides a 2-amino-5-piperidinylimidazolone compound of formula (I) also methods and compositions for the inhibition s-secretase (BACE) treatment s-amyloid deposits neurofibrillary tangles.

参考文章(21)
James Joseph Erdei, Joseph Raymond Stock, Yinfa Yan, Iwan Suwandi Gunawan, Michael Sotirios Malamas, Pawel Nowak, Cycloalkyl amino-hydantoin compounds and use thereof for beta-secretase modulation ,(2006)
Dominick Anthony Quagliato, Patrick Michael Andrae, Yi Fan, Dihydrospiro[dibenzo[a,d][7]annulene-5,4'-imidazol] compounds for the inhibition of beta-secretase ,(2007)
Dominick Anthony Quagliato, Albert Jean Robichaud, Yanfang Li, Michael Sotirios Malamas, Ping Zhou, Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation ,(2006)
Dominick Anthony Quagliato, Patrick Michael Andrae, William Ronald Solvibile, William Floyd Fobare, James Joseph Erdei, Yinfa Yan, Iwan Suwandi Gunawan, Michael Sotirios Malamas, Ping Zhou, AMINO-5-(5-MEMBERED)HETERO-ARYLIMIDAZOLONE COMPOUNDS AND THE USE THEREOF FOR beta-SECRETASE MODULATION ,(2006)
Hiroyuki Setoi, Tatsuya Zenkoh, Kentaro Sato, Hirokazu Tanaka, Hitoshi Sawada, Takehiko Ohkawa, Benzamide derivatives and their use as vasopressin antagonists ,(1996)
Yu Hui, Keith Douglas Barnes, Iwan Suwandi Gunawan, Matthew Robert Johnson, Michael Sotirios Malamas, James Joseph Erdei, Diphenylimidazopyrimidine and -imidazole amines as inhibitors of b-secretase ,(2005)
Boyd Lynn Harrison, Iwan Suwandi Gunawan, Michael Sotirios Malamas, James Joseph Erdei, Pawel Wojciech Nowak, Amino-imidazolones for the inhibition of beta-secretase ,(2006)
Albert Jean Robichaud, Michael Sotirios Malamas, William Ronald Solvibile, Jeffrey Scott Condon, William Floyd Fobare, Frank Eldridge Lovering, Amino-pyridines as inhibitors of .beta.-secretase ,(2006)
Daniel Kuzmich, Yancey David Ward, Leah Lynn Frye, Terence Alfred Kelly, Jiang-Ping Wu, Small molecules useful in the treatment of inflammatory disease ,(2000)