pfmdr1 Amplification Associated with Clinical Resistance to Mefloquine in West Africa: Implications for Efficacy of Artemisinin Combination Therapies
作者： B. Witkowski , X. Iriart , P. N. Soh , S. Menard , M. Alvarez
DOI: 10.1128/JCM.01057-10
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摘要: We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted Africa and associated vitro resistance pfmdr1 copy number amplification. This case raises question presence evolution this genotype Africa, which is also known to alter susceptibility artemisinin combination therapy (ACT).
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