.beta.-l-2'-deoxynucleosides for the treatment of resistant hbv strains and combination therapies
作者： David Standring , April L. Patty , Maria Seifer , Jean-Pierre Sommadossi
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摘要: It has been discovered that β-L-2′-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided includes administering β-L-2′-deoxynucleoside or its pharmaceutically acceptable salt, ester prodrug. In addition, preventing mutation from occurring naive and/or suppressing the emergence of double mutant (L528M/M552V) also
lens.org参考文章(105)
Robins Mj, Selective deoxygenation and modification at C2' of nucleosides. Nucleic acids symposium series. pp. 1- 4 ,(1982)
Lilia M. Beauchamp, Therapeutic valine esters of acyclovir and pharmaceutically acceptable salts thereof ,(1988)
Johan C. F. Söderlund, Elias S. J. Arnér, Mitochondrial versus cytosolic activities of deoxyribonucleoside salvage enzymes. Advances in Experimental Medicine and Biology. ,vol. 370, pp. 201- 204 ,(1995) , 10.1007/978-1-4615-2584-4_43
Karl Y. Hostetler, Antiviral liponucleosides: treatment of hepatitis B ,(1992)
Anna Karlsson, Chaoyong Zhu, Magnus Johansson, Incorporation of Nucleoside Analogs into Nuclear or Mitochondrial DNA Is Determined by the Intracellular Phosphorylation Site Journal of Biological Chemistry. ,vol. 275, pp. 26727- 26731 ,(2000) , 10.1016/S0021-9258(19)61436-5
R K Bestwick, G L Moffett, C K Mathews, Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells. Journal of Biological Chemistry. ,vol. 257, pp. 9300- 9304 ,(1982) , 10.1016/S0021-9258(18)34068-7
Xilin Zhao, Yuzhi Dong, Karl Drlica, Dosing and development of antimicrobial and antiviral drugs determined by restriction of resistant mutant selection ,(1999)
SN Si Ahmed, D Tavan, C Pichoud, F Berby, L Stuyver, M Johnson, P Merle, H Abidi, C Trépo, F Zoulim, Early Detection of Viral Resistance by Determination of Hepatitis B Virus Polymerase Mutations in Patients Treated by Lamivudine for Chronic Hepatitis B Hepatology. ,vol. 32, pp. 1078- 1088 ,(2000) , 10.1053/JHEP.2000.19619
Michael Kevin Bamat, Reid Warren von Borstel, Acyl deoxyribonucleoside derivatives and uses thereof ,(1988)
Chung K. Chu, Yung-Chi Cheng, Hea O. Kim, Kirupathevy Shanmuganathan, Method of treating or preventing hepatitis b virus ,(1992)