ß-L-2'-DEOXYNUCLEOSIDES FOR THE TREATMENT OF RESISTANT HBV STRAINS AND COMBINATION THERAPIES
作者： David Standring , April L. Patty , Maria Seifer , Jean-Pierre Sommadossi
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摘要: It has been discovered that s-L-2'-deoxynucleosides are active against drugresistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided includes administering s-L-2'deoxynucleoside or its pharmaceutically acceptable salt, ester prodrug. In addition, preventing mutation from occurring naive s-L-2'-deoxynucleoside and/or suppressing the emergence of double mutant (L528M/M552V) also (3-L-2'-deoxynucleoside
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