Aspects of matrix effects in applications of liquid chromatography-mass spectrometry to forensic and clinical toxicology—a review

摘要: In the last decade, liquid chromatography coupled to (tandem) mass spectrometry (LC–MS(−MS)) has become a versatile technique with many routine applications in clinical and forensic toxicology. However, it is well-known that ionization LC–MS(−MS) prone so-called matrix effects, i.e., alteration response due presence of co-eluting compounds may increase (ion enhancement) or reduce suppression) analyte. Since first reports on such numerous papers have been published this matter subject reviewed several times. none existing reviews specifically addressed aspects effects particular interest relevance toxicology, for example methods multi-analyte systematic toxicological analysis (alternative) matrices almost exclusively analyzed meconium, hair, oral fluid, decomposed samples postmortem This review article will therefore focus these issues, critically discussing experiments results Moreover, provides guidance performance studies procedures