Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women

摘要: Background: Soy protein or its components may protect against the atherosclerotic cardiovascular disease (CVD) risk factors total homocysteine (tHcy), C-reactive (CRP), and excess body iron, which generally increase with menopause. Objective: The primary objective of this study was to determine independent effect soy isoflavones phytate on CVD in postmenopausal women. secondary identify [blood lipids, oxidative stress indexes, serum ferritin, plasma folate, vitamin B-12, mass index (BMI)] contributing tHcy CRP concentrations. Design: In a double-blind, 6-wk study, 55 women aged 47-72 y were randomly assigned 1 4 (40 g/d) isolate treatments: native isoflavone (n = 14), low 13), 14). We measured iron tHcy, CRP, BMI. Results: significantly reduced (P 0.017), transferrin saturation 0.027), ferritin 0.029), whereas had no any variables. At baseline, BMI highly correlated (r 0.39, P 0.003) 0.55, < 0.0001), HDL cholesterol -0.30, 0.02). Multiple regression analysis showed that LDL contributed (R 2 19.9%, overall variance tHcy. Conclusion: Consuming phytate-rich foods maintaining healthy weight reduce