125 I brachytherapy of locally advanced non-small-cell lung cancer after one cycle of first-line chemotherapy：a comparison with best supportive care
作者： Jingjing Song , Xiaoxi Fan , Zhongwei Zhao , Minjiang Chen , Weiqian Chen
DOI: 10.2147/OTT.S129903
关键词:
摘要: OBJECTIVES The objective of this study was to assess the efficacy computed tomography (CT)-guided 125I brachytherapy alone in improving survival and quality life patients with unresectable locally advanced non-small-cell lung cancer (NSCLC) after one cycle first-line chemotherapy. PATIENTS AND METHODS Sixteen NSCLC were treated CT-guided chemotherapy (group A). who received only best supportive care B) matched up group A. Primary end point included survival, secondary assessment safety, effectiveness brachytherapy, improvement life. RESULTS two groups well balanced terms age, disease histology, tumor stage, location, performance status (P>0.05). median follow-up time 16 months (range, 3-30). total response rate 75.0% A, which significantly higher than that B (0.0%) (P<0.01). progression-free 4.80 for A 1.35 (P<0.001). Kaplan-Meier analysis showed 9.4±0.3 versus 8.4±0.1 (P=0.013). Tumor-related symptoms relieved, markedly improved B. CONCLUSION compared care.
sci-hub.se 参考文章(38)
Makoto Kobuke, Hiromi Kumon, Yasutomo Nasu, Ryuta Tanimoto, Shin Ebara, Susumu Kanazawa, Kohei Edamura, Yasuyuki Kobayashi, Tomoko Kobayashi, Hiroyuki Nose, Mitsuhiro Takemoto, Yoshihisa Katayama, Daisuke Manabe, Takeshi Saika, Iodine-125 Seed Implantation (Permanent Brachytherapy) for Clinically Localized Prostate Cancer Acta Medica Okayama. ,vol. 62, pp. 9- 13 ,(2008)
L. Zheng, J. Zhang, T. Song, J. Zhang, G. Yu, Y. Zhang, 125I seed implant brachytherapy for the treatment of parotid gland cancers in children and adolescents. Strahlentherapie Und Onkologie. ,vol. 189, pp. 401- 406 ,(2013) , 10.1007/S00066-013-0313-6
Daohong Zhou, Lijian Shao, Douglas R. Spitz, Reactive oxygen species in normal and tumor stem cells. Advances in Cancer Research. ,vol. 122, pp. 1- 67 ,(2014) , 10.1016/B978-0-12-420117-0.00001-3
Zhong-Min Wang, Jian Lu, Tao Liu, Ke-Min Chen, Gang Huang, Fen-Ju Liu, CT-guided interstitial brachytherapy of inoperable non-small cell lung cancer Lung Cancer. ,vol. 74, pp. 253- 257 ,(2011) , 10.1016/J.LUNGCAN.2011.03.006
Ang Qu, Hao Wang, Jinna Li, Junjie Wang, Jingjia Liu, Yuzhu Hou, Li Huang, Yong Zhao, Biological effects of (125)i seeds radiation on A549 lung cancer cells: G2/M arrest and enhanced cell death. Cancer Investigation. ,vol. 32, pp. 209- 217 ,(2014) , 10.3109/07357907.2014.905585
Atsunori Yorozu, Nobuko Kuroiwa, Akane Takahashi, Kazuhito Toya, Shiro Saito, Toru Nishiyama, Yasuto Yagi, Tomoki Tanaka, Yutaka Shiraishi, Toshio Ohashi, Permanent prostate brachytherapy with or without supplemental external beam radiotherapy as practiced in Japan: Outcomes of 1300 patients Brachytherapy. ,vol. 14, pp. 111- 117 ,(2015) , 10.1016/J.BRACHY.2014.06.008
Rafael Martínez-Monge, María Pagola, Isabel Vivas, José María López-Picazo, CT-guided permanent brachytherapy for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC) Lung Cancer. ,vol. 61, pp. 209- 213 ,(2008) , 10.1016/J.LUNGCAN.2007.12.016
Winnie Lee, Benedict D.T Daly, Thomas A DiPetrillo, Donna M Morelli, Andrew C Neuschatz, Jody Morr, Mark J Rivard, Limited Resection for Non-Small Cell Lung Cancer: Observed Local Control With Implantation of I-125 Brachytherapy Seeds The Annals of Thoracic Surgery. ,vol. 75, pp. 237- 242 ,(2003) , 10.1016/S0003-4975(02)04098-5
Zhang Fu-Jun, Li Chuan-Xing, Zhang Liang, Wu Pei-hong, Jiao De-Chao, Duan Guang-Feng, Short- to mid-term evaluation of CT-guided 125I brachytherapy on intra-hepatic recurrent tumors and/or extra-hepatic metastases after liver transplantation for hepatocellular carcinoma Cancer Biology & Therapy. ,vol. 8, pp. 585- 590 ,(2009) , 10.4161/CBT.8.7.7902
M. Ayadi, N. Zahra, J. Thariat, G. Bouilhol, P. Boissard, P. Van Houtte, L. Claude, F. Mornex, Radiothérapie conformationnelle avec modulation d'intensité dans les carcinomes bronchiques non à petites cellules Cancer Radiotherapie. ,vol. 18, pp. 406- 413 ,(2014) , 10.1016/J.CANRAD.2014.06.009