Cutaneous balloon cell dermatofibroma (fibrous histiocytoma).

摘要: Dermatofibroma (DF) or cutaneous fibrous histiocytoma is a common benign skin tumor that exhibits multiple, distinct histologic variants. Although clear cell DF has been described in the literature, balloon degeneration causing phenotype not reported to date. Herein, we describe clinicopathologic findings of arising on heel 43-year-old man. Clinically, it presented as enlarging tan-white, ulcerated, firm 1.5 cm nodule, clinically suspected be pyogenic granuloma. Excisional biopsy revealed circumscribed populated by mostly and spindle cells. A zonal arrangement separated varied cells where most superficial, polypoid area showed large, polygonal cells; mid-dermal zone demonstrated transition between cells, epithelioid deep dermal had storiform with fascicles coarse collagen bundles. CD10+ > CD68+ Factor XIIIa+ immunophenotype was identified negative immunolabeling for S-100 protein, HMB-45, cytokeratin AE1/AE3, desmin, smooth muscle actin, lysozyme, leukocyte antigen (LCA). Ultrastructurally, were filled empty, nonmembrane bound vacuoles varying size. No recurrence after complete excision 7 months follow up. change, likely secondary persistent irritation, should added differential diagnosis primary metastatic neoplasms showing such melanocytic nevi renal carcinoma, respectively.