CD10 Is Expressed in Most Epithelioid Hemangioendotheliomas: A Potential Diagnostic Pitfall

摘要: Abstract Context.—Epithelioid hemangioendothelioma (EHE) is a vascular neoplasm that occasionally difficult to distinguish from primary/metastatic carcinomas, particularly when EHEs express keratins. We recently encountered an EHE with strong CD10 positivity mimicking renal cell carcinoma. Objective.—To examine sensitivity and specificity of in EHE. Design.—Nine were stained keratins, factor VIII, CD31, CD34, CD10. Mimics also retrieved Results.—The patients included 5 men 4 women. Patients ranged age 24 74 years. Tumors located liver (3), skin (2), lung/pleura sternomastoid mediastinum (1 each). Two had metastases. All positive for markers. A total 7 9 primary tumors expressed cytoplasmic intracytoplasmic luminal The 2 metastases positive, whereas negative. Of the mimics, showed staining 23 cases: 3 carcino...